Restoration of ethanol-compromised Th1 responses by sodium orthovanadate

Serge Ostrovidov, Laurence M. Howard, Masato Ikeda, Akiko Ikeda, Carl Waltenbaugh

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Alcohol consumption often diminishes antigen-specific cell-mediated immunity. In alcohol-consuming mice IFN-γ and delayed-type hypersensitivity (DTH) responses are blunted, although antigen-specific T cell proliferation and IL-2 responses are largely unaffected, suggesting that alcohol differentially affects signal transduction pathways. In the present report we explore the use of the phosphatase inhibitor, Na3VO4 to restore IFN-γ secretion in the presence of ethanol both in vivo and in vitro. We show that Na3VO4 restores IFN-γ in vitro and antigen-specific DTH in vivo to the levels seen in alcohol non-consuming mice. Our data support the contention that ethanol, by up-regulating phosphotyrosine phosphatase, diminishes the IFN-γ signal transduction pathway.

    Original languageEnglish
    Pages (from-to)1239-1245
    Number of pages7
    JournalInternational immunology
    Volume14
    Issue number11
    DOIs
    Publication statusPublished - 2002 Nov 1

    Keywords

    • Alcohol
    • IFN-γ
    • Mouse
    • NaVO
    • Protein tyrosine phosphatase

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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  • Cite this

    Ostrovidov, S., Howard, L. M., Ikeda, M., Ikeda, A., & Waltenbaugh, C. (2002). Restoration of ethanol-compromised Th1 responses by sodium orthovanadate. International immunology, 14(11), 1239-1245. https://doi.org/10.1093/intimm/dxf088