Respiratory Muscle Strength and Gas Exhange in Neuromuscular Diseases: Comparison with Chronic Pulmonary Emphysema and Idiopathic Pulmonary Fibrosis

Yoshihiro Nishimura, Wataru Hida, Osamu Taguchi, Makoto Sakurai, Masakazu Ichinose, Hiroshi Inoue, Tamotsu Takishima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nishimura, Y., Hida, W., Taguchi, O., Sakurai, M., Ichinose, M., Inoue, H. and Takishima, T. Respiratory Muscle Strength and Gas Exchange in Neuromuscular Diseases: Comparison with Chronic Pulmonary Emphysema and Idiopathic Pulmonary Fibrosis. Tohoku J. Exp. Med., 1989, 159 (1), 57-68-To examine whether or not the respiratory muscle weakness is correlated with decrease in arterial oxygen tension (PaO2), respiratory muscle and pulmonary functions in 14 patients with neuromuscular diseases (NMD) were studied and compared with those of 12 patients with chronic pulmonary emphysema (CPE) and 15 patients with idiopathic pulmonary fibrosis (IPF). Respiratory muscle strength was assessed by maximal static inspiratory and expiratory mouth pressure at three lung volumes (RV, FRC and TLC). Although mean pulmonary functions in NMD showed virtually normal function, respiratory muscle strength was significantly less than the corresponding values in CPE and IPF. In NMD, maximal inspiratory mouth pressure at RV level (PImax) correlated positively with %TLC and %VC (r=0.652 and r=0.536, respectively). Moreover, PImax was significantly correlated with PaO2 (r=0.561), but not with PaCO2. Maximal expiratory mouth pressure at TLC (PEmax) correlated positively with %TLC and %VC. In CPE and IPF, respiratory muscle strength had no correlation with PaO2 and PaCO2. These findings suggest that inspiratory muscle dysfunction in NMD may be one of the factors responsible for determination of the level of hypoxemia and lung volume.

Original languageEnglish
Pages (from-to)57-68
Number of pages12
Journalthe tohoku journal of experimental medicine
Volume159
Issue number1
DOIs
Publication statusPublished - 1989 Jan 1

Keywords

  • Respiratory failure
  • hypoxemia and lung volume
  • maximal mouth pressure
  • pulmonary function test

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Respiratory Muscle Strength and Gas Exhange in Neuromuscular Diseases: Comparison with Chronic Pulmonary Emphysema and Idiopathic Pulmonary Fibrosis'. Together they form a unique fingerprint.

  • Cite this