Abstract
Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.
Original language | English |
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Pages (from-to) | 439-443 |
Number of pages | 5 |
Journal | Journal of Veterinary Medical Science |
Volume | 63 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2001 Apr |
Externally published | Yes |
Keywords
- Canine
- Cardiopulmonary reflex
- Nasal afferent
ASJC Scopus subject areas
- veterinary(all)