Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs

Arata Kanamaru, Tatsushi Mutoh, Ryohei Nishimura, Nobuo Sasaki, Masayoshi Kuwahara, Hirokazu Tsubone

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalJournal of Veterinary Medical Science
Volume63
Issue number4
DOIs
Publication statusPublished - 2001 Apr 1
Externally publishedYes

Keywords

  • Canine
  • Cardiopulmonary reflex
  • Nasal afferent

ASJC Scopus subject areas

  • veterinary(all)

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