Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs

Arata Kanamaru; Tatsushi Mutoh; Ryohei Nishimura; Nobuo Sasaki; Masayoshi Kuwahara; Hirokazu Tsubone

doi:10.1292/jvms.63.439

Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs

Arata Kanamaru, Tatsushi Mutoh, Ryohei Nishimura, Nobuo Sasaki, Masayoshi Kuwahara, Hirokazu Tsubone

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.

Original language	English
Pages (from-to)	439-443
Number of pages	5
Journal	Journal of Veterinary Medical Science
Volume	63
Issue number	4
DOIs	https://doi.org/10.1292/jvms.63.439
Publication status	Published - 2001 Apr
Externally published	Yes

Keywords

Canine
Cardiopulmonary reflex
Nasal afferent

ASJC Scopus subject areas

veterinary(all)

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10.1292/jvms.63.439

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Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs. / Kanamaru, Arata; Mutoh, Tatsushi; Nishimura, Ryohei; Sasaki, Nobuo; Kuwahara, Masayoshi; Tsubone, Hirokazu.

In: Journal of Veterinary Medical Science, Vol. 63, No. 4, 04.2001, p. 439-443.

Research output: Contribution to journal › Article › peer-review

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abstract = "Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.",

keywords = "Canine, Cardiopulmonary reflex, Nasal afferent",

author = "Arata Kanamaru and Tatsushi Mutoh and Ryohei Nishimura and Nobuo Sasaki and Masayoshi Kuwahara and Hirokazu Tsubone",

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AU - Kanamaru, Arata

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AU - Nishimura, Ryohei

AU - Sasaki, Nobuo

AU - Kuwahara, Masayoshi

AU - Tsubone, Hirokazu

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N2 - Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.

AB - Cardiopulmonary reflexes elicited by capsaicin (CAPS) instilled into the nasal passages were determined in 6 anesthetized dogs breathing spontaneously. Nasal instillation of CAPS (10 μg/m/, 10 ml) induced: 1) apneic response characterized by an increase in expiration time; 2) bronchoconstrictor response characterized by an increase in lung resistance and a decrease in dynamic compliance; and 3) cardiovascular response characterized by a decrease in heart rate and an increase in arterial blood pressure. These reflex responses to CAPS were attenuated by pretreatment with a higher dose of CAPS (100 μg/ml, 10 ml), suggesting desensitization of CAPS-sensitive endings. These results suggest that marked cardiopulmonary reflexes are produced by nasal CAPS instillation, which may result, at least in part, from stimulation of nasal CAPS-sensitive sensory afferents.

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Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs

Abstract

Keywords

ASJC Scopus subject areas

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