Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer

Nobuya Katagiri; Takuya Shiraishi; Hiroshi Sato; Akemi Toyota; Chikara Kaneko; Keisuke Yusa; Tomoko Oh-hara; Takashi Tsuruo

doi:10.1016/0006-291X(92)91172-M

Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer

Nobuya Katagiri, Takuya Shiraishi, Hiroshi Sato, Akemi Toyota, Chikara Kaneko, Keisuke Yusa, Tomoko Oh-hara, Takashi Tsuruo

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Two enantiomers of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) which showed a potent and selective anti-HIV effects have been synthesized and evaluated against human immuno-deficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA is expressed solely by the (-) isomer.

Original language	English
Pages (from-to)	154-159
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	184
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(92)91172-M
Publication status	Published - 1992 Apr 15

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Katagiri, N., Shiraishi, T., Sato, H., Toyota, A., Kaneko, C., Yusa, K., Oh-hara, T., & Tsuruo, T. (1992). Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer. Biochemical and biophysical research communications, 184(1), 154-159. https://doi.org/10.1016/0006-291X(92)91172-M

Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer. / Katagiri, Nobuya; Shiraishi, Takuya; Sato, Hiroshi; Toyota, Akemi; Kaneko, Chikara; Yusa, Keisuke; Oh-hara, Tomoko; Tsuruo, Takashi.

In: Biochemical and biophysical research communications, Vol. 184, No. 1, 15.04.1992, p. 154-159.

Research output: Contribution to journal › Article › peer-review

Katagiri, N, Shiraishi, T, Sato, H, Toyota, A, Kaneko, C, Yusa, K, Oh-hara, T & Tsuruo, T 1992, 'Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer', Biochemical and biophysical research communications, vol. 184, no. 1, pp. 154-159. https://doi.org/10.1016/0006-291X(92)91172-M

Katagiri, Nobuya ; Shiraishi, Takuya ; Sato, Hiroshi ; Toyota, Akemi ; Kaneko, Chikara ; Yusa, Keisuke ; Oh-hara, Tomoko ; Tsuruo, Takashi. / Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer. In: Biochemical and biophysical research communications. 1992 ; Vol. 184, No. 1. pp. 154-159.

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