Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer

Nobuya Katagiri, Takuya Shiraishi, Hiroshi Sato, Akemi Toyota, Chikara Kaneko, Keisuke Yusa, Tomoko Oh-hara, Takashi Tsuruo

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15 Citations (Scopus)

Abstract

Two enantiomers of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) which showed a potent and selective anti-HIV effects have been synthesized and evaluated against human immuno-deficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA is expressed solely by the (-) isomer.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalBiochemical and biophysical research communications
Volume184
Issue number1
DOIs
Publication statusPublished - 1992 Apr 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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