Resistant maltodextrin decreases micellar solubility of lipids and diffusion of bile salt micelles and suppresses incorporation of micellar fatty acids into caco-2 cells

Ikuo Ikeda, Kyouhei Tamakuni, Tomomi Sakuma, Ran Ozawa, Nao Inoue, Yuka Kishimoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalJournal of nutritional science and vitaminology
Volume62
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Bile salt micelles
  • Caco-2 cells
  • Lipid absorption
  • Resistant maltodextrin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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