Resignation and return to work in patients receiving allogeneic hematopoietic cell transplantation close up

Saiko Kurosawa, Takuhiro Yamaguchi, Ayako Mori, Tomoko Matsuura, Takehiko Mori, Masatsugu Tanaka, Tadakazu Kondo, Yukari Umemoto, Hideki Goto, Satoshi Yoshioka, Shinichiro Machida, Takahiko Sato, Yuta Katayama, Seiko Kato, Katsuhiro Shono, Ishikazu Mizuno, Shin ichiro Fujiwara, Akio Kohno, Miyako Takahashi, Takahiro Fukuda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose: To characterize the issues regarding work and employment specific to allogeneic hematopoietic cell transplantation (allo-HCT) survivors, we conducted a nationwide cross-sectional questionnaire survey. Methods: We targeted allo-HCT survivors employed at diagnosis, aged 20–64 at survey, and survived ≥2 years without relapse. The questionnaire included the timing of and reasons for resignation (termination of employment contract), and patient-related, HCT-related, work-related, and HCT center-related factors. Results: A total of 1048 eligible participants were included in the analysis (response rate, 60%). The median time after allo-HCT was 5 years (range, 2–30) at the time of survey. After diagnosis, 41% of participants resigned from work throughout the course of treatment. The most frequent timing of the first resignation was “after discharge post-HCT” (46%), followed by “from diagnosis to initial treatment” (27%). Factors significantly associated with resignation included female gender, older age, and part-time employment. Favorable factors included the presence of occupational health staff at the workplace, employment of ≥10 years, and self-employed/freelance. After resignation, the overall incidence of return to work with some accommodations was 76% at 5 years after HCT, but it was 52% without any accommodation. Conclusions: Overall, the rate of resignation was 41%, and the most frequent timing of resignation was after discharge post-HCT, accounting for approximately half of the resignations (46%). Workplace accommodations increased the rate of return to work from 52% to 76%. Implications for Cancer survivors: Early detection of employment-related concerns and support throughout the treatment process are necessary for patients receiving allo-HCT.

Original languageEnglish
JournalJournal of Cancer Survivorship
Publication statusPublished - 2022 Oct


  • Allogeneic hematopoietic cell transplantation
  • Resignation from work, employment, return to work
  • Survivorship

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)


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