Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether

Yu Liu, Ying Wei Yang, Yun Song, Heng Yi Zhang, Fei Ding, Takehiko Wada, Yoshihisa Inoue

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Do you recognise this peptide? Novel 6,6′-(2,2′-dithio-bis(2- (benzoylamino)ethylamino))-bridged bis(β-CD), such as the one shown here, showed good to excellent residue selectivities of up to 28 for several nonaromatic dipeptides with the complex stability sequence of Glu-Glu < Gly-Gly < Leu-Gly < Met-Met < Gly-Pro < Gly-Leu, and also a high sequence selectivity of 5.0 for Gly-Leu versus Leu-Gly.

Original languageEnglish
Pages (from-to)868-871
Number of pages4
JournalChemBioChem
Volume5
Issue number6
DOIs
Publication statusPublished - 2004 Jun 7
Externally publishedYes

Keywords

  • Binding
  • Cyclodextrins
  • Peptides
  • Recognition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Residue- and sequence-selective binding of nonaromatic dipeptides by bis(β-cyclodextrin) with a functional tether'. Together they form a unique fingerprint.

Cite this