Requirement of the tec family tyrosine kinase Btk29A for courtship memory in Drosophila Males

Kazuya Sunouchi, Masayuki Koganezawa, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    A male Drosophila that is not successful in courtship will reduce his courtship efforts in the next encounter with a female. This courtship suppression persists for more than 1 h in wild-type males. The Btk29AficP mutant males null for the Btk29A type 2 isoform, a fly homolog of the nonreceptor tyrosine kinase Btk, show no courtship suppression, while Btk29A hypomorphic males exhibit a rapid decline in courtship suppression, leading to its complete loss within 30 min. The males of a revertant stock or Btk29AficP males that are also mutant for parkas, a gene encoding the presumptive negative regulator of Btk29A, exhibit normal courtship suppression. Since another behavioral assay has shown that Btk29AficP mutants are sensitization-defective, we hypothesize that the mutant flies are unable to maintain the neural excitation state acquired by experience, resulting in the rapid loss of courtship suppression. Copyright

    Original languageEnglish
    Pages (from-to)165-174
    Number of pages10
    JournalArchives of Insect Biochemistry and Physiology
    Volume91
    Issue number3
    DOIs
    Publication statusPublished - 2016 Mar 1

    Keywords

    • D. melanogaster
    • Experience-dependence
    • Plasticity
    • Short-term memory
    • Src

    ASJC Scopus subject areas

    • Physiology
    • Biochemistry
    • Insect Science

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