Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

K. Ogasawara, S. Hida, N. Azimi, Y. Tagaya, T. Sato, T. Yokochi-Fukuda, T. A. Waldmann, T. Taniguchi, S. Taki

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Abstract

Natural killer (NK) cells are critical for both innate and adaptive immunity. The development of NK cells requires interactions between their progenitors and the bone-marrow microenvironment; however, little is known about the molecular nature of such interactions. Mice that do not express the transcription factor interferon-regulatory factor-1 (IRF-1; such mice are IRF-1(-/-) mice) have been shown to exhibit a severe NK-cell deficiency. Here we demonstrate that the lack of IRF-1 affects the radiation-resistant cells that constitute the microenvironment required for NK-cell development, but not the NK-cell progenitors themselves. We also show that IRF-1(-/-) bone- marrow cells can generate functional NK cells when cultured with the cytokine interleukin-15 (refs 9-12) and that the interleukin-15 gene is transcriptionally regulated by IRF-1. These results reveal, for the first time, a molecular mechanism by which the bone-marrow microenvironment supports NK-cell development.

Original languageEnglish
Pages (from-to)700-703
Number of pages4
JournalNature
Volume391
Issue number6668
DOIs
Publication statusPublished - 1998 Feb 12
Externally publishedYes

ASJC Scopus subject areas

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    Ogasawara, K., Hida, S., Azimi, N., Tagaya, Y., Sato, T., Yokochi-Fukuda, T., Waldmann, T. A., Taniguchi, T., & Taki, S. (1998). Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature, 391(6668), 700-703. https://doi.org/10.1038/35636