Representation of functional category in the monkey prefrontal cortex and its rule-dependent use for behavioral selection

Ken Ichiro Tsutsui, Takayuki Hosokawa, Munekazu Yamada, Toshio Iijima

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Humans, monkeys, and other animals are considered to have the cognitive ability to use functional categories—that is, stimulus groups based on functional equivalence independent of physical properties. To investigate the underlying neural mechanisms of the use of functional categories, we recorded single-unit activity in the prefrontal cortex of monkeys performing a behavioral task in which the rule-dependent usage of functional category was needed to select an appropriate response. We found a neural correlate of functional categories on the single-neuron level and found that category information is coded independently of other task-relevant information such as rule and contingency information. Analysis of the time course of the information activation suggested that contingency information used for action selection is derived by integrating incoming category information with rule information maintained throughout a session. Such neural computation can be considered as the neural background of flexible behavioral control based on category and rule.

    Original languageEnglish
    Pages (from-to)3038-3048
    Number of pages11
    JournalJournal of Neuroscience
    Volume36
    Issue number10
    DOIs
    Publication statusPublished - 2016 Mar 9

    Keywords

    • Functional category
    • Monkey
    • Prefrontal cortex
    • Single-unit recording

    ASJC Scopus subject areas

    • Neuroscience(all)

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