TY - JOUR
T1 - Replenishing B lymphocytes in health and disease
AU - Zhang, Qingzhao
AU - Iida, Ryuji
AU - Shimazu, Tomoyuki
AU - Kincade, Paul W.
N1 - Funding Information:
The authors thank Karla Garrett for technical assistance and Shelli Wasson for editorial assistance. This work was supported by National Institutes of Health Grants AI020069 and HL107138 (P.W.K.). P.W.K. holds the William H. and Rita Bell Endowed Chair in Biomedical Research.
PY - 2012/4
Y1 - 2012/4
N2 - The path from hematopoietic stem cells (HSCs) to functional B lymphocytes has long been appreciated as a basic model of differentiation, but much clinically relevant information has also been obtained. It is now possible to conduct single cell studies with increasingly high resolution, revealing that individual stem and progenitor cells differ from each other with respect to differentiation potential and fates. B lymphopoiesis is now seen as a gradual and unsynchronized process where progenitors eventually become B lineage restricted. Major milestones have been identified, but a precise sequence need not be followed and oscillation between states is possible. It is not yet clear if this versatility has survival value, but information is accumulating about infections and age-related changes.
AB - The path from hematopoietic stem cells (HSCs) to functional B lymphocytes has long been appreciated as a basic model of differentiation, but much clinically relevant information has also been obtained. It is now possible to conduct single cell studies with increasingly high resolution, revealing that individual stem and progenitor cells differ from each other with respect to differentiation potential and fates. B lymphopoiesis is now seen as a gradual and unsynchronized process where progenitors eventually become B lineage restricted. Major milestones have been identified, but a precise sequence need not be followed and oscillation between states is possible. It is not yet clear if this versatility has survival value, but information is accumulating about infections and age-related changes.
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U2 - 10.1016/j.coi.2011.12.007
DO - 10.1016/j.coi.2011.12.007
M3 - Review article
C2 - 22236696
AN - SCOPUS:84859157933
VL - 24
SP - 196
EP - 203
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 2
ER -