Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice

Kensuke Murakami, Takeo Kondo, Pak H. Chan

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

To clarify the role of reperfusion in DNA damage following focal cerebral ischemia, we determined the distribution of cells with DNA fragmentation following permanent or transient focal ischemia. Less DNA-damaged cells were observed in the permanent than in the transient group in the ischemic core, but there was no difference in the boundary zone. We conclude that reperfusion following transient ischemia may exacerbate neuronal death following DNA damage.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalBrain research
Volume751
Issue number1
DOIs
Publication statusPublished - 1997 Mar 14
Externally publishedYes

Keywords

  • DNA fragmentation
  • TUNEL staining
  • focal cerebral ischemia
  • reperfusion injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice'. Together they form a unique fingerprint.

Cite this