TY - JOUR
T1 - Repatterning in amphibian limb regeneration
T2 - A model for study of genetic and epigenetic control of organ regeneration
AU - Yakushiji, Nayuta
AU - Yokoyama, Hitoshi
AU - Tamura, Koji
PY - 2009/7
Y1 - 2009/7
N2 - Limb regeneration is an excellent model for understanding organ reconstruction along PD, AP and DV axes. Re-expression of genes involved in axial pattern formation is essential for complete limb regeneration. The cellular positional information in the limb blastema has been thought to be a key factor for appropriate gene re-expression. Recently, it has been suggested that epigenetic mechanisms have an essential role in development and regeneration processes. In this review, we discuss how epigenetic mechanisms may be involved in the maintenance of positional information and the regulation of gene re-expression during limb regeneration.
AB - Limb regeneration is an excellent model for understanding organ reconstruction along PD, AP and DV axes. Re-expression of genes involved in axial pattern formation is essential for complete limb regeneration. The cellular positional information in the limb blastema has been thought to be a key factor for appropriate gene re-expression. Recently, it has been suggested that epigenetic mechanisms have an essential role in development and regeneration processes. In this review, we discuss how epigenetic mechanisms may be involved in the maintenance of positional information and the regulation of gene re-expression during limb regeneration.
KW - Axial pattern formation
KW - Epigenetic regulation
KW - Organ regeneration
KW - Positional information
UR - http://www.scopus.com/inward/record.url?scp=67649419076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649419076&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2008.12.007
DO - 10.1016/j.semcdb.2008.12.007
M3 - Review article
C2 - 19146968
AN - SCOPUS:67649419076
SN - 1084-9521
VL - 20
SP - 565
EP - 574
JO - Seminars in Cell Biology
JF - Seminars in Cell Biology
IS - 5
ER -