Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration

Nayuta Yakushiji, Hitoshi Yokoyama, Koji Tamura

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Limb regeneration is an excellent model for understanding organ reconstruction along PD, AP and DV axes. Re-expression of genes involved in axial pattern formation is essential for complete limb regeneration. The cellular positional information in the limb blastema has been thought to be a key factor for appropriate gene re-expression. Recently, it has been suggested that epigenetic mechanisms have an essential role in development and regeneration processes. In this review, we discuss how epigenetic mechanisms may be involved in the maintenance of positional information and the regulation of gene re-expression during limb regeneration.

Original languageEnglish
Pages (from-to)565-574
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number5
DOIs
Publication statusPublished - 2009 Jul

Keywords

  • Axial pattern formation
  • Epigenetic regulation
  • Organ regeneration
  • Positional information

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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