Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshifumi Sugitani, Kouichi Ozaki, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Toshimitsu Hamasaki, Toshihiro Tanaka, Masatsugu Hori, Issei Komuro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalInternational heart journal
Volume55
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Genetics
  • Secondary prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Hara, M., Sakata, Y., Nakatani, D., Suna, S., Usami, M., Matsumoto, S., Sugitani, T., Ozaki, K., Nishino, M., Sato, H., Kitamura, T., Nanto, S., Hamasaki, T., Tanaka, T., Hori, M., & Komuro, I. (2014). Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study. International heart journal, 55(3), 190-196. https://doi.org/10.1536/ihj.13-288