Renal vasodilatation induced by DOI, a 5-HT2 receptor agonist, in the canine kidney

Shoji Tetsuo, Kiyomoto Hideyasu, Tamaki Toshlaki, Iwao Hiroshi, Abe Youichi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

An intrarenal infusion of (±)-l-(2,5-dimethoxy-4-iodophenyl)-2-arninopropane (DOI), a selective 5-HT2 agonist, at a rate of 5 μg/min in anesthetized dogs resulted in an increase in renal blood flow (RBF) without any transient decrease as usually observed during the infusion of S-HT. During the infusion, urine flow (UF) and urinary sodium excretion rates (UNAV) increased along with RBF while the mean arterial pressure and glomerular filtration rate did not change. After pretreatment with ritanserin, a selective S-HT2 antagonist, DOI failed to increase RBF, UF and UNA V. It is concluded that DOI produces renal vasodilatation mediated via 5-HT2 receptors and has a diuretic action. DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane); 5-HT2 receptors; Renal vasodilatation; Diuretic action.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalEuropean Journal of Pharmacology
Volume190
Issue number1-2
DOIs
Publication statusPublished - 1990 Nov 6

ASJC Scopus subject areas

  • Pharmacology

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