Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

Masahiro Kohzuki, Masahiro Kamimoto, Xue Min Wu, Hong Lan Xu, Takaguki Kawamura, Nobuyoshi Mori, Makoto Nagasaka, Hajime Kurosawa, Naoyoshi Minami, Masayuki Kanazawa, Takao Saito, Kazunori Yoshida

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Objectives Patients with chronic renal failure are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of renal disease. Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously hypertensive rats (SHR) with chronic renal failure. We also assessed the effects of exercise and antihypertensive therapy on renal function. Design and methods Eight-week-old SHR were subjected to 5/6 nephrectomy by removal of the left kidney and excision of two-thirds of the right kidney. The rats were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an angiotensin converting enzyme (ACE) inhibitor, enalapril (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, losartan (5 mg/kg per day, i.p.), for 4 weeks. Results Chronic EX significantly attenuated the increase in proteinuria (P<0.01) and significantly protected against increases in the index of glomerular sclerosis (IGS). Both enalapril and losartan with EX significantly decreased blood pressure (P<0.001), and further decreased the IGS. In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of IGS (P<0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean proteinuria (weeks 1-4) (all P<0.0001). Conclusions These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of rats. Moreover, the antihypertensive therapy has additional renal-protective effects in this model of rats.

Original languageEnglish
Pages (from-to)1877-1882
Number of pages6
JournalJournal of hypertension
Volume19
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • Blood pressure
  • Exercise
  • Kidney
  • Proteinuria
  • Renal failure
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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