Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients with Primary Adosteronism

Hiroko Ogata, Yuto Yamazaki, Yuta Tezuka, Xin Gao, Kei Omata, Yoshikiyo Ono, Yoshihide Kawasaki, Tomoaki Tanaka, Hidekazu Nagano, Norio Wada, Yutaka Oki, Akira Ikeya, Kenji Oki, Yoshiyu Takeda, Mitsuhiro Kometani, Kazunori Kageyama, Ken Terui, Celso E. Gomez-Sanchez, Shujun Liu, Ryo MorimotoKensuke Joh, Hiroshi Sato, Mariko Miyazaki, Akihiro Ito, Yoichi Arai, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The rapid progression of chronic kidney disease and higher incidence of cardiovascular complications are well known in patients with hyperaldosteronism. However, detailed renal histopathologic characteristics of this disease have remained unknown. Therefore, renal biopsy specimens of 19 cases with unilateral hyperaldosteronism were compared with 22 autopsy renal cases of estimated glomerular filtration rate-matched essential hypertension without nephropathy or endocrine disorders to explore the hyperaldosteronism-specific histopathologic renal changes in this study. Global and segmental glomerulosclerosis, interstitial fibrosis, infiltration of inflammatory cells, arteriosclerosis, hyalinization of arterioles and immunoreactivity of mineralocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1 and 2, and renin were all quantitatively evaluated. The ultrastructural analysis was added in 3 hyperaldosteronism cases. Both mineralocorticoid receptor (P<0.01) and 11β-hydroxysteroid dehydrogenase type 2 (P<0.01) were significantly higher in renal tubules of hyperaldosteronism, which could result in enhancement of in situ aldosterone effects in hyperaldosteronism kidneys. Interstitial fibrosis was significantly more marked in hyperaldosteronism (P<0.01). The proportion of segmental glomerulosclerosis was also significantly higher in hyperaldosteronism (P<0.01). There were no significant differences of global glomerulosclerosis between 2 groups (P=0.08). Glomerular size was significantly larger in hyperaldosteronism (P<0.01). In medium size artery, luminal stenosis tended to be more marked (P=0.08), and intima-To-media ratio was significantly lower (P=0.02) in hyperaldosteronism. Arteriolar hyalinization was significantly more pronounced (P<0.01), especially at efferent arterioles (P<0.01) in hyperaldosteronism. Results above demonstrated more pronounced whole renal damages in hyperaldosteronism. Results of our present study also indicated the potential clinical significance of early intervention using mineralocorticoid receptor antagonists or blockers.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
Issue number2
Publication statusPublished - 2021 Aug 1


  • 11βHSD
  • aldosterone
  • histopathology
  • hypertension
  • mineralocorticoid receptor
  • renin

ASJC Scopus subject areas

  • Internal Medicine


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