Renal infarct volume and renal function decline in acute and chronic phases

Saeko Kagaya, Ojima Yoshie, Hirotaka Fukami, Hiroyuki Sato, Ayako Saito, Yoichi Takeuchi, Ken Matsuda, Tasuku Nagasawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Acute renal infarction (ARI) is a rare disease. ARI causes decline in renal function in both the acute and chronic phases. However, the correlation between the volume of the infarction and degree of renal function decline has not been fully investigated. Therefore, we aimed to examine the relationship between the volume of the infarction and degree of renal function decline. Methods: We performed a single-center, retrospective, observational study investigating clinical parameters and the volume of the infarction. The volume of the infarction was measured using reconstructed computed tomography data. Results: A total of 39 patients (mean age, 72.6 ± 13.2 years; men, 59%) were enrolled. The median infarction volume was 45 mL (interquartile range, 14–91 mL). The volume of the infarction was significantly associated with the peak lactate dehydrogenase (LDH) level (median, 728 IU/L; interquartile range, 491–1227 U/L) (r = 0.58, p < 0.01) and the degree of renal function decline in both acute and chronic phases (r = −0.44, −0.38, respectively, p < 0.05). The peak LDH level was significantly correlated with the degree of renal function decline in the acute phase but not in the chronic phase (r = −0.35, −0.21; p < 0.05, N.S., respectively). Conclusions: The volume of the infarction may be a factor in the degree of renal function decline in ARI. Therefore, assessment of infarct volume in ARI is important.

Original languageEnglish
Pages (from-to)1030-1034
Number of pages5
JournalClinical and experimental nephrology
Volume21
Issue number6
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • 3-Dimensional reconstructed computed tomography
  • Acute kidney injury
  • Acute renal infarction
  • Atrial fibrillation
  • Chronic kidney disease

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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    Kagaya, S., Yoshie, O., Fukami, H., Sato, H., Saito, A., Takeuchi, Y., Matsuda, K., & Nagasawa, T. (2017). Renal infarct volume and renal function decline in acute and chronic phases. Clinical and experimental nephrology, 21(6), 1030-1034. https://doi.org/10.1007/s10157-017-1399-4