TY - JOUR
T1 - Renal effects of a nitric oxide donor, NOC7, in anesthetized rabbits
AU - Adachi, Yuichiro
AU - Hashimoto, Kazuyuki
AU - Ono, Naoto
AU - Yoshida, Makoto
AU - Suzuki-Kusaba, Mizue
AU - Hisa, Hiroaki
AU - Satoh, Susumu
PY - 1997/4
Y1 - 1997/4
N2 - Intrarenal arterial infusion of angiotensin II (4 ng/kg per min) reduced glomerular filtration rate and urinary Na+ excretion without affecting fractional Na+ excretion. Infusion of norepinephrine (30 ng/kg per min) reduced both urinary Na+ excretion and fractional Na+ excretion with a slight hypofiltration. The angiotensin II- and the norepinephrine-induced renal responses were suppressed during simultaneous infusion of a spontaneous nitric oxide donor 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl 1-triazene (NOC 7, 30 ng/kg per min) which itself had little influence on the renal parameters. The results suggest that in the rabbit kidney in vivo NOC 7 can interfere with the angiotensin II-induced hypofiltration and norepinephrine-evoked tubular reabsorption and thereby suppresses their antinatriuretic actions.
AB - Intrarenal arterial infusion of angiotensin II (4 ng/kg per min) reduced glomerular filtration rate and urinary Na+ excretion without affecting fractional Na+ excretion. Infusion of norepinephrine (30 ng/kg per min) reduced both urinary Na+ excretion and fractional Na+ excretion with a slight hypofiltration. The angiotensin II- and the norepinephrine-induced renal responses were suppressed during simultaneous infusion of a spontaneous nitric oxide donor 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl 1-triazene (NOC 7, 30 ng/kg per min) which itself had little influence on the renal parameters. The results suggest that in the rabbit kidney in vivo NOC 7 can interfere with the angiotensin II-induced hypofiltration and norepinephrine-evoked tubular reabsorption and thereby suppresses their antinatriuretic actions.
KW - (Rabbit)
KW - Angiotensin II
KW - Kidney
KW - NOC 7 (1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl 1-triazene)
KW - Nitric oxide (NO)
KW - Norepinephrine
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UR - http://www.scopus.com/inward/citedby.url?scp=0030988036&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(97)10009-7
DO - 10.1016/S0014-2999(97)10009-7
M3 - Article
C2 - 9145776
AN - SCOPUS:0030988036
VL - 324
SP - 223
EP - 226
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -