Renal effects of a nitric oxide donor, NOC7, in anesthetized rabbits

Yuichiro Adachi, Kazuyuki Hashimoto, Naoto Ono, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Intrarenal arterial infusion of angiotensin II (4 ng/kg per min) reduced glomerular filtration rate and urinary Na+ excretion without affecting fractional Na+ excretion. Infusion of norepinephrine (30 ng/kg per min) reduced both urinary Na+ excretion and fractional Na+ excretion with a slight hypofiltration. The angiotensin II- and the norepinephrine-induced renal responses were suppressed during simultaneous infusion of a spontaneous nitric oxide donor 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl 1-triazene (NOC 7, 30 ng/kg per min) which itself had little influence on the renal parameters. The results suggest that in the rabbit kidney in vivo NOC 7 can interfere with the angiotensin II-induced hypofiltration and norepinephrine-evoked tubular reabsorption and thereby suppresses their antinatriuretic actions.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalEuropean Journal of Pharmacology
Volume324
Issue number2-3
DOIs
Publication statusPublished - 1997 Apr

Keywords

  • (Rabbit)
  • Angiotensin II
  • Kidney
  • NOC 7 (1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl 1-triazene)
  • Nitric oxide (NO)
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology

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