@article{00d0428d649e4db7811937a98bc6b418,
title = "Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons",
abstract = "An unnatural terpenoid scaffold containing a bicyclo[5.4.0]undecane moiety, as well as a salvialane skeleton based on an intramolecular C-C bond formation strategy were synthesized. Such a strategy was made possible by the removal of strained E-olefin conformations of the humulene skeleton. Some compounds were identified to show PPARα antagonist activity.",
author = "Takehiro Nishimura and Junya Kawai and Yoshiteru Oshima and Haruhisa Kikuchi",
note = "Funding Information: This work was supported in part by the Grants-in-Aid for Scientific Research (no. 16H03279) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; the Platform Project for Supporting in Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)), and Practical Research for Innovative Cancer Control from AMED under grant nos. JP18am0101095 and JP18am0101100, the Shorai Foundation for Science and Technology, Kobayashi International Scholarship Foundation, the Takeda Science Foundation, Suzuken Memorial Foundation, and the Uehara Memorial Foundation. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = nov,
day = "16",
doi = "10.1021/acs.orglett.8b03259",
language = "English",
volume = "20",
pages = "7317--7320",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "22",
}