Remodeling of vascular endothelial cells exposed to fluid shear stress: Experimental and numerical approach

Toshiro Ohashi, Masaaki Sato

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Vascular endothelial cells are an interface between blood vessel walls and blood flow, and play important roles in physiological functions. Since endothelial cell responses to fluid shear stress have been implicated in the localization of atherosclerosis, the effect of shear stress on endothelial cell morphology and functions has been exclusively studied. After applying fluid shear stress, cultured endothelial cells show marked elongation and orientation in the flow direction. In addition, thick stress fibers of actin filaments appear and align along the cell long axis. Thus, the endothelial cell morphology is closely related to the cytoskeletal structure. The purpose of this review is to summarize endothelial cell responses to fluid flow which have been studied, focusing on the changes in cell shape and cytoskeletal structure. Numerical studies to simulate local flow field at the cellular level and the resulting intracellular stresses are also reviewed.

Original languageEnglish
Pages (from-to)40-59
Number of pages20
JournalFluid Dynamics Research
Volume37
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - 2005

Keywords

  • Atherosclerosis
  • Cytoskeleton
  • Finite element analysis
  • Fluid shear stress
  • Remodeling
  • Vascular endothelial cells

ASJC Scopus subject areas

  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Fluid Flow and Transfer Processes

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