Remodeling of hippocampal network in pilocarpine-treated mice expressing synaptopHluorin in the mossy fiber terminals

Shin Ito, Toru Ishizuka, Hiromu Yawo

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Pilocarpine-induced seizures induce an ectopic projection of hippocampal mossy fibers (MFs). Here, the sprouting was directly examined using TV-42 mice that express synaptopHluorin (SpH) selectively in the MF boutons. The SpH was ectopically expressed in the inner molecular layer (IML) of the dentate gyrus in typical mice after seizures, but were not always accompanied by the zinc fluorescence. The expression of SpH also has a tendency to be enhanced in layers of the CA3a region. It is suggested that the abnormal connection of neurons is more widespread than expected based on the previous zinc-detecting methods.

    Original languageEnglish
    Pages (from-to)25-31
    Number of pages7
    JournalNeuroscience Research
    Volume74
    Issue number1
    DOIs
    Publication statusPublished - 2012 Sep

    Keywords

    • Epilepsy
    • Hippocampus
    • Pilocarpine
    • Seizure
    • Synaptogenesis
    • SynaptopHluorin
    • Transgenic
    • Zinc

    ASJC Scopus subject areas

    • Neuroscience(all)

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