Remodeling of extracellular matrices initiates and advances calcification during development and healing of bones and teeth

Yasuyuki Sasano, Megumi Nakamura, Hiroshi Okata, Akiko Henmi, Yasuto Mikami

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Osteoblasts, odontoblasts, cementoblasts and ameloblasts form calcified tissues. Following the initial deposition of hydroxyapatite, these extracellular matrix-producing cells make the calcified matrix more mature. Previous studies have provided a basis for the hypothesis that the cells express enzymes and remodel their specific extracellular matrix proteins to advance calcification during development of the tissue. This review summarizes our recent studies and relevant previous reports on expression of enzymes such as matrix metalloproteinases in development of bones and teeth as well as healing of bones.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
Journaljournal of oral biosciences
Volume54
Issue number1
DOIs
Publication statusPublished - 2012 Feb

Keywords

  • Bone
  • Calcification
  • Extracellular matrix
  • MMP
  • Tooth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dentistry(all)

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