Remnant lipoprotein particles are taken up into myocardium through VLDL receptor - A possible mechanism for cardiac fatty acid metabolism

Akihisa Kamataki, Sadao Takahashi, Katsuhiko Masamura, Tadao Iwasaki, Hiroaki Hattori, Hironobu Naiki, Kazuya Yamada, Jinya Suzuki, Isamu Miyamori, Juro Sakai, Takahiro Fujino, Tokuo T. Yamamoto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The VLDL (very low-density lipoprotein) receptor is a peripheral lipoprotein receptor expressing in fatty acid active tissues abundantly. In the Balb/c fasting mice VLDL receptor as well as LPL (lipoprotein lipase) FAT (fatty acid translocase)/CD36 H-FABP (heart-type fatty acid-binding protein) ACS (acyl-CoA synthetase) and LCAD (long-chain acyl-CoA dehydrogenase) expressions increased. An electron microscopic examination indicated the lipid droplets that accumulated in the hearts of fasting Balb/c mice. During the development of SD (Sprague-Dawley) rats VLDL receptor LPL FAT/CD36 H-FABP ACS and LCAD mRNAs concomitantly increased with growth. However PK (pyruvate kinase) mRNA expression was negligible. In cultured neonatal rat cardiomyocytes VLDL receptor expression increased with days in culture. Oil red-O staining showed that cardiomyocytes after 7 days in culture (when the VLDL receptor protein is present) accumulated β-migrating VLDL. Thereby we showed that the cardiac VLDL receptor pathway for delivery of remnant lipoprotein particles might be part of a cardiac fatty acid metabolism.

Original languageEnglish
Pages (from-to)1007-1013
Number of pages7
JournalBiochemical and biophysical research communications
Volume293
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Fatty acid metabolism
  • Fatty acid transporters
  • Lipoprotein lipase
  • Lipoprotein metabolism
  • VLDL receptor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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