Remarkable selectivity in derivatization and protection of hydroxy groups of 51-hydroxyCTX3C: Chemoselective synthesis of biotin-conjugated ciguatoxin derivatives

Yuuki Ishihara, Keisuke Miyazaki, Shuji Yamashita, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ciguatoxins, principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers that exert their toxicities by binding to the voltage-sensitive sodium channels. We report C7/C51 chemoselective derivatization of 51-hydroxyCTX3C applicable for synthesis of biological probes.

Original languageEnglish
Pages (from-to)886-887
Number of pages2
JournalChemistry Letters
Volume38
Issue number9
DOIs
Publication statusPublished - 2009 Aug 10

ASJC Scopus subject areas

  • Chemistry(all)

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