Remarkable acceleration for the deamination of carbocyclic purine nucleosides by adenosine deaminase under high-pressure.

N. Katagiri; T. Shiraishi; A. Toyota; H. Sato; C. Kaneko

Remarkable acceleration for the deamination of carbocyclic purine nucleosides by adenosine deaminase under high-pressure.

N. Katagiri, T. Shiraishi, A. Toyota, H. Sato, C. Kaneko

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.

Original language	English
Pages (from-to)	95-96
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	29
Publication status	Published - 1993

ASJC Scopus subject areas

Medicine(all)

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title = "Remarkable acceleration for the deamination of carbocyclic purine nucleosides by adenosine deaminase under high-pressure.",

abstract = "Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.",

author = "N. Katagiri and T. Shiraishi and A. Toyota and H. Sato and C. Kaneko",

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journal = "Nucleic acids symposium series",

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T1 - Remarkable acceleration for the deamination of carbocyclic purine nucleosides by adenosine deaminase under high-pressure.

AU - Katagiri, N.

AU - Shiraishi, T.

AU - Toyota, A.

AU - Sato, H.

AU - Kaneko, C.

PY - 1993

Y1 - 1993

N2 - Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.

AB - Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.

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JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

SN - 0261-3166

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