Abstract
Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.
Original language | English |
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Pages (from-to) | 95-96 |
Number of pages | 2 |
Journal | Nucleic acids symposium series |
Issue number | 29 |
Publication status | Published - 1993 |
ASJC Scopus subject areas
- Medicine(all)