Remarkable acceleration for the deamination of carbocyclic purine nucleosides by adenosine deaminase under high-pressure.

N. Katagiri, T. Shiraishi, A. Toyota, H. Sato, C. Kaneko

Research output: Contribution to journalArticlepeer-review

Abstract

Deamination of an anti-HIV carbocyclic adenine nucleoside, 9-[c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine [(+/-)-BCA] and (+/-)-diamino-carbovir by adenosine deaminase under high-pressure (4 kbar) was carried out. Deamination of the former gave the corresponding (-)-hypoxanthine derivative whereas that of the latter produced (-)-carbovir having anti-HIV activity. The enantiomeric excess (e.e.) of both products was nearly 100%.

Original languageEnglish
Pages (from-to)95-96
Number of pages2
JournalNucleic acids symposium series
Issue number29
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Medicine(all)

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