TY - JOUR
T1 - Relevance of oxidative and carbonyl stress to long-term uremic complications
AU - Miyata, T.
AU - Kurokawa, K.
AU - Van Ypersele De Strihou, C.
N1 - Funding Information:
These studies were supported by grants from Research for the Future Program of the Japan Society for the Promotion of Science (96 l00303) to T.M. and by research grants from the U.S. National Institutes of Health (AG-11472 and DK-19971).
PY - 2000
Y1 - 2000
N2 - Oxidative stress is a disturbance of balance between oxidants and antioxidant species. The existence of an increased oxidative stress in chronic renal failure is supported by evidence of increased lipid, carbohydrate, and protein oxidation products in plasma and cell membrane. Recent studies have implicated the oxidative stress in the nonenzymatic biochemistry leading to irreversible protein modifications. Reactive oxygen species may directly alter proteins with the eventual formation of oxidized amino acids. Alternatively, reactive carbonyl compounds formed by the oxidation of carbohydrates and lipids may indirectly lead to advanced glycation or lipoxidation of proteins. Chronic uremia is associated with increased modification of protein caused by reactive carbonyl compounds derived from both carbohydrates and lipids. Increased carbonyl modification of proteins subsequently results in the rise of plasma and tissue contents of advanced glycation end products and advanced lipoxidation end products, in which the deleterious biological effects have been revealed. This article focuses on the irreversible nonenzymatic modification of proteins, which might, at least in part, contribute to the development of complications associated with chronic renal failure and long-term dialysis, such as atherosclerosis and dialysis-related amyloidosis.
AB - Oxidative stress is a disturbance of balance between oxidants and antioxidant species. The existence of an increased oxidative stress in chronic renal failure is supported by evidence of increased lipid, carbohydrate, and protein oxidation products in plasma and cell membrane. Recent studies have implicated the oxidative stress in the nonenzymatic biochemistry leading to irreversible protein modifications. Reactive oxygen species may directly alter proteins with the eventual formation of oxidized amino acids. Alternatively, reactive carbonyl compounds formed by the oxidation of carbohydrates and lipids may indirectly lead to advanced glycation or lipoxidation of proteins. Chronic uremia is associated with increased modification of protein caused by reactive carbonyl compounds derived from both carbohydrates and lipids. Increased carbonyl modification of proteins subsequently results in the rise of plasma and tissue contents of advanced glycation end products and advanced lipoxidation end products, in which the deleterious biological effects have been revealed. This article focuses on the irreversible nonenzymatic modification of proteins, which might, at least in part, contribute to the development of complications associated with chronic renal failure and long-term dialysis, such as atherosclerosis and dialysis-related amyloidosis.
KW - Amyloidosis
KW - Atherosclerosis
KW - Glycation
KW - Hemodialysis
KW - Lipoxidation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0033865719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033865719&partnerID=8YFLogxK
U2 - 10.1046/j.1523-1755.2000.07615.x
DO - 10.1046/j.1523-1755.2000.07615.x
M3 - Article
C2 - 10936808
AN - SCOPUS:0033865719
VL - 58
SP - S120-S125
JO - Kidney International, Supplement
JF - Kidney International, Supplement
SN - 0098-6577
IS - 76
ER -