Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer

Yoshitaka Kinouchi, Nobuo Hiwatashi, Seiichi Higashioka, Fumio Nagashima, Masaki Chida, Takayoshi Toyota

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13 informative patients exhibited ROI of IGF2; furthermore, normal mucosa from 3 of these 5 patients also showed weak biallelic expression of IGF2. ROI of IGF2 may thus also play a role in colorectal cancer.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalCancer Letters
Volume107
Issue number1
DOIs
Publication statusPublished - 1996 Oct 1

Keywords

  • Colorectal cancer
  • Imprinting
  • Insulin-like growth factor II

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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