Relative power contributions of unit discharges simultaneously recorded in the mesencephalic reticular formation

Tohru Kodama, Yoshiko Honda, Mitsuyuki Nakao, Seisho Sato, Mitsuaki Yamamoto

Research output: Contribution to journalArticlepeer-review

Abstract

In order to investigate mutual interactions between neuronal discharges in the mesencepahlic reticular formation, relative power contributions (RPC) were estimated during sleep-wake cycles and serotonin (5HT)-depleted conditions by the administration of parachlorophenylalanine (PCPA). The RPC for most of the neurons dominated in the lower frequency range below 0.4 Hz during rapid eye movement (REM) sleep and the PCPA-treated conditions, which were qualitatively reproduced by the neural network model under global disinhibition. The results supported the hypothesis that the peculiar dynamics of neuronal activities during REM sleep, 1/f fluctuations, were generated by neuronal interactions augmented by the release from the global inhibition of 5HT.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Volume54
Issue number3
DOIs
Publication statusPublished - 2000 Jun

Keywords

  • 1/f fluctuations
  • Mesencephalic reticular formation
  • Neural network model
  • Parachlorophenylalanine
  • Relative power contribution
  • Serotonin (5HT), sleep-wake cycles

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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