Relationships for recombinant interleukin-2-stimulated mixed lymphocyte tumor extract reaction between peripheral blood lymphocytes and regional node lymphocytes in gastric cancer patients

C. C. Tseng, Y. Nio, M. Tsubono, M. Fukumoto, T. Tobe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To investigate the relationship between 'systemic' antitumor immunity and 'local' antitumor immunity with respect to the histopathological stage of gastric cancer, interleukin-2 stimulated mixed lymphocyte tumor extract reactions (ILS-MLTR) of peripheral blood lympocytes (PBL) and regional node lymphocytes (RNL) were evaluated in 59 gastric cancer patients. ILS-MLTRs of both PBL and RNL decreased with the advance of cancer stage, but ILS-MLTRs of PBL were always lower than those of RNL. Positive correlations in MLTR between PBL and RNL were found in patients with depth of invasion to muscularis propria and serosa and peritoneal dissemination. Inverse correlations between PBL and RNL were noted in patients with stage IV and distant nodal involvement. These results suggest that variations in the anticancer immunities might be effectively managed by an immunotherapy which is designed according to the responsiveness in the immune parameter ILS-MLTR.

Original languageEnglish
Pages (from-to)927-932
Number of pages6
JournalAnticancer research
Volume12
Issue number3
Publication statusPublished - 1992 Jan 1

Keywords

  • Gastric cancer
  • IL-2
  • Mixed lymphocyte tumor extract reaction (MLTR)
  • Tumor immunology
  • Tumor-host relationship

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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