Abstract
To investigate the relationship between 'systemic' antitumor immunity and 'local' antitumor immunity with respect to the histopathological stage of gastric cancer, interleukin-2 stimulated mixed lymphocyte tumor extract reactions (ILS-MLTR) of peripheral blood lympocytes (PBL) and regional node lymphocytes (RNL) were evaluated in 59 gastric cancer patients. ILS-MLTRs of both PBL and RNL decreased with the advance of cancer stage, but ILS-MLTRs of PBL were always lower than those of RNL. Positive correlations in MLTR between PBL and RNL were found in patients with depth of invasion to muscularis propria and serosa and peritoneal dissemination. Inverse correlations between PBL and RNL were noted in patients with stage IV and distant nodal involvement. These results suggest that variations in the anticancer immunities might be effectively managed by an immunotherapy which is designed according to the responsiveness in the immune parameter ILS-MLTR.
| Original language | English |
|---|---|
| Pages (from-to) | 927-932 |
| Number of pages | 6 |
| Journal | Anticancer research |
| Volume | 12 |
| Issue number | 3 |
| Publication status | Published - 1992 Jan 1 |
Keywords
- Gastric cancer
- IL-2
- Mixed lymphocyte tumor extract reaction (MLTR)
- Tumor immunology
- Tumor-host relationship
ASJC Scopus subject areas
- Oncology
- Cancer Research
