Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in japanese: The INTERLIPID study

Zhao Guo, Katsuyuki Miura, Tanvir Chowdhury Turin, Atsushi Hozawa, Nagako Okuda, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Katsushi Yoshita, Takashi Kadowaki, Sohel R. Choudhury, Yasuyuki Nakamura, Beatriz L. Rodriguez, J. David Curb, Paul Elliott, Jeremiah Stamler, D. Hirotsugu Ueshima

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14 Citations (Scopus)

Abstract

Aim: There have been few studies on the relationships of the dietary polyunsaturated to saturated fatty acid ratio (P/S) to cardiovascular risk factors and metabolic syndrome. We hypothesized that there would be favorable relationships. & Methods: Metabolic cardiovascular risk factors from dietary nutrient intake were investigated in 1,004 men and women aged 40-59 years from 4 population samples of Japanese. Multiple linear regression analysis was used to examine the relationship of the dietary P/S ratio to the following risk factors: hemoglobin A1c, blood pressure, serum triglycerides, LDL and total cholesterol, and HDL-cholesterol. Adjusted odds ratio of having metabolic syndrome was also calculated. & Results: The dietary P/S ratio was significantly and inversely related to serum total and LDL cholesterol with control for possible confounding variables. We did not find any significant relationship between the P/S ratio and single metabolic risk factors or the prevalence of metabolic syndrome. & Conclusions: Managing the P/S ratio is important to control serum LDL-cholesterol; however, increasing the P/S ratio may not improve metabolic risk factors. Other countermeasures, such as weight control, greater physical activity, and smoking cessation should be recommended to prevent and control metabolic syndrome.

Original languageEnglish
Pages (from-to)777-784
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Volume17
Issue number8
DOIs
Publication statusPublished - 2010 Jan 1

Keywords

  • Japanese
  • Metabolic syndrome
  • P/s ratio
  • Polyunsaturated fatyy acid
  • Saturated fatty acid

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

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    Guo, Z., Miura, K., Turin, T. C., Hozawa, A., Okuda, N., Okamura, T., Saitoh, S., Sakata, K., Nakagawa, H., Okayama, A., Yoshita, K., Kadowaki, T., Choudhury, S. R., Nakamura, Y., Rodriguez, B. L., Curb, J. D., Elliott, P., Stamler, J., & Ueshima, D. H. (2010). Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in japanese: The INTERLIPID study. Journal of atherosclerosis and thrombosis, 17(8), 777-784. https://doi.org/10.5551/jat.4135