Relationship of Soluble Fas with Body Mass Index in Healthy Japanese Adults

Akiko Tamakoshi, Koji Suzuki, Yingsong Lin, Yoshinori Ito, Kiyoko Yagyu, Shogo Kikuchi, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito TanabeKoji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Recent studies have linked elevated serum sFas levels to atherosclerotic disease among patients. Confirming an association between obesity and serum sFas levels in healthy subjects would facilitate our understanding of obesity and its related disorders. We therefore analyzed serum sFas levels of 8,541 subjects selected as controls for a nested case-control study within the JACC Study. Body mass index (BMI) was calculated as the indicator of obesity based on self-reported height and weight. We found a statistically significant positive association between serum sFas levels and BMI among our apparently healthy subjects. Our result suggests that serum sFas rises to down-regulate increased apoptosis in atherogenesis processes caused by obesity.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 2009 Dec

Keywords

  • BMI
  • Healthy controls
  • Japan collaborative cohort study
  • sFAS

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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