Relationship between RANTES polymorphisms and respiratory syncytial virus bronchiolitis in a Japanese infant population

Satoshi Hattori, Naoki Shimojo, Yoichi Mashimo, Yuzaburo Inoue, Yasuhiko Ono, Yoichi Kohno, Yoshitaka Okamoto, Akira Hata, Yoichi Suzuki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Respiratory syncytial virus (RSV) is the most important virus associated with bronchiolitis in in infants and young children. The regulated upon activation, normal T-cell expressed and secreted protein (RANTES, also known as CCL5) appears to be a key player in the etiology of RSV-infected airway inflammation. In this study, we genotyped three single-nucleotide polymorphisms in the RANTES gene: -403G/A, -28C/G, and In1.1T/C in 59 infants with severe RSV bronchiolitis and 201 control subjects. The frequencies of the -403G/A + A/A, -28C/G - G/G, and In1.1T/C + C/C genotypes were significantly lower in patients with severe RSV bronchiolitis than in control subjects, and the frequencies of the -403A, -28G, and In1.1C alleles were significantly lower in RSV patients than in control subjects. The present results suggest that RANTES polymorphisms may confer risk for severe RSV bronchiolitis.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalJapanese journal of infectious diseases
Volume64
Issue number3
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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