Relationship between pathological characteristics and radiological findings on perfusion mr imaging of meningioma

Atsushi Saito, Takashi Inoue, Shinsuke Suzuki, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

Abstract

Few studies have reviewed the roles of perfusion magnetic resonance (MR) imaging in the histo-pathological examination of meningiomas. We analyzed the relationships between radiological findings on perfusion MR imaging and pathological characteristics such as origin of the tumor, mitotic activity, pathological subtype, and perifocal edema formation. The subjects were 21 surgical cases of meningioma preoperatively evaluated by perfusion MR imaging. A region of interest (ROI) was set inside of the tumor, and perifocal edema of the same size, cerebral blood volume (CBV), and cerebral blood flow (CBF) on perfusion MR and diffusion-weighted (DW) imaging were analyzed. These radiological data were evaluated in comparison with histopatho-logical characteristics. On perfusion MR imaging, the average ratio of CBV against the contralat-eral side was 6.43 (1.13–20.0) and that of CBF was 7.73 (1.34–11.3). There was no significant relationship with perfusion MR imaging data, tumor volume, or perifocal edema volume. However, the large peritumoral edema group often had a higher CBV and CBF than the non-large peritumoral edema group. The skull base group had a significantly higher CBV and lower signal intensity on DW images than the non-skull base group. Signal intensity on DW images was higher in grade II or III than in grade I. Perfusion MR imaging data revealed that the higher ratio of peritumoral edema against tumor size was associated with higher blood flow and blood volume under intratumoral circulatory conditions, and that skull base meningioma had a higher blood volume than non-skull base meningioma.

Original languageEnglish
Pages (from-to)228-235
Number of pages8
JournalNeurologia medico-chirurgica
Volume61
Issue number3
DOIs
Publication statusPublished - 2021

Keywords

  • Circulation
  • Magnetic resonance
  • Meningioma
  • Perfusion

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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