Relationship between hypoxemia and fibrillation potential firing rate in denervated muscle

Shin Ichi Izumi, Akio Tsubahara, Naoichi Chino

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The effects of hypoxia and ischemia on the firing rate of fibrillation potentials in denervated rat muscle were examined. We recorded electromyograms from the denervated left extensor digitorum longus muscle. Hypoxia was induced by low-oxygen ventilation. Ischemia was established by ligating the abdominal aorta and inferior vena cava, with or without extracorporeal hindlimb perfusion. The fibrillation potential firing rate correlated with the Pa(O2) (P < 0.0001) and temperature (P = 0.0001). Fibrillation potentials disappeared after the initiation of ischemia and reappeared after restitution of blood flow; they disappeared during ischemia with extracorporeal perfusion. The attenuation curves for the firing rate of fibrillation potentials during ischemia were well-described by exponential curves, but there was no significant difference in the attenuation constants for circulatory arrest and perfusion with a physiologic salt solution. We conclude that the fibrillation potential firing rate is proportional to oxygen supply, presumably because of the rate of aerobic metabolism.

Original languageEnglish
Pages (from-to)933-936
Number of pages4
JournalMuscle and Nerve
Volume22
Issue number7
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Denervation
  • Electromyography
  • Fibrillation potentials
  • Hypoxia
  • Ischemia

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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