TY - JOUR
T1 - Relationship between dietary intake and microalbuminuria
T2 - Findings from the Takahata study
AU - Sato, Masahiro
AU - Hozawa, Atsushi
AU - Konta, Tsuneo
AU - Shao, Li
AU - Otani, Katsumi
AU - Narimatsu, Hiroto
AU - Sasaki, Satoshi
AU - Kato, Takeo
AU - Kubota, Isao
AU - Yamashita, Hidetoshi
AU - Kayama, Takamasa
AU - Fukao, Akira
N1 - Funding Information:
This study was supported by a grant-in-aid from the 21st Century Center of Excellence (COE) and the Global COE Program of the Japan Society for the Promotion of Science. This study was also supported by a Grant-in-Aid for Young Scientists (A) (21689018) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2012/2
Y1 - 2012/2
N2 - Background: Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population. Methods: We analyzed 675 men and 924 women who did not have diabetes. Participants who had a urinary albumin-to-creatinine ratio (UACR) ≥300 mg/g, who did not complete a questionnaire regarding food frequency and who did not provide complete urine measurements were excluded. Nutrient intake was assessed by validated food frequency questionnaire. Microalbuminuria was defined as UACR ≥30 mg/g. The relationship between dietary nutrient intake and microalbuminuria was examined using a multiple logistic regression model adjusted for age, total energy intake, body mass index, smoking status, systolic blood pressure and use of antihypertensive medication. Results: No significant association was observed among the men. The multiple adjusted odds ratios (95% confidence interval) of having microalbuminuria per 1 standard deviation increase in total protein (%kcal), animal protein (%kcal), animal protein (g/day), animal fat, niacin, carbohydrate and β-cryptoxanthin among the women were 1.33 (1.07-1.66), 1.35 (1.09-1.66), 1.42 (1.08-1.88), 1.29 (1.05-1.59), 1.28 (1.04-1.57), 0.73 (0.58-0.92) and 0.76 (0.59-0.996), respectively. The multiple adjusted odds ratio (95% confidence interval) of having microalbuminuria in the highest quintile of n-3 polyunsaturated fatty acids compared with the lowest was 2.16 (1.03-4.54). Conclusion: Less animal protein and more β-cryptoxanthin in the diet might help to prevent microalbuminuria. Prospective studies including controlled trials are required to confirm this conclusion.
AB - Background: Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population. Methods: We analyzed 675 men and 924 women who did not have diabetes. Participants who had a urinary albumin-to-creatinine ratio (UACR) ≥300 mg/g, who did not complete a questionnaire regarding food frequency and who did not provide complete urine measurements were excluded. Nutrient intake was assessed by validated food frequency questionnaire. Microalbuminuria was defined as UACR ≥30 mg/g. The relationship between dietary nutrient intake and microalbuminuria was examined using a multiple logistic regression model adjusted for age, total energy intake, body mass index, smoking status, systolic blood pressure and use of antihypertensive medication. Results: No significant association was observed among the men. The multiple adjusted odds ratios (95% confidence interval) of having microalbuminuria per 1 standard deviation increase in total protein (%kcal), animal protein (%kcal), animal protein (g/day), animal fat, niacin, carbohydrate and β-cryptoxanthin among the women were 1.33 (1.07-1.66), 1.35 (1.09-1.66), 1.42 (1.08-1.88), 1.29 (1.05-1.59), 1.28 (1.04-1.57), 0.73 (0.58-0.92) and 0.76 (0.59-0.996), respectively. The multiple adjusted odds ratio (95% confidence interval) of having microalbuminuria in the highest quintile of n-3 polyunsaturated fatty acids compared with the lowest was 2.16 (1.03-4.54). Conclusion: Less animal protein and more β-cryptoxanthin in the diet might help to prevent microalbuminuria. Prospective studies including controlled trials are required to confirm this conclusion.
KW - Japanese
KW - Lifestyle
KW - Microalbuminuria
KW - Nutrients
KW - Risk factor
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U2 - 10.1007/s10157-011-0539-5
DO - 10.1007/s10157-011-0539-5
M3 - Article
C2 - 21964760
AN - SCOPUS:84858291866
VL - 16
SP - 147
EP - 155
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
SN - 1342-1751
IS - 1
ER -