Relationship between body mass index and preoperative treatment response to aromatase inhibitor exemestane in postmenopausal patients with primary breast cancer

Masahiro Takada, Shigehira Saji, Norikazu Masuda, Katsumasa Kuroi, Nobuaki Sato, Hiroyuki Takei, Yutaka Yamamoto, Shinji Ohno, Hiroko Yamashita, Kazufumi Hisamatsu, Kenjiro Aogi, Hiroji Iwata, Takayuki Ueno, Hironobu Sasano, Masakazu Toi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: Some studies have shown that high body mass index (BMI) is associated with inferior outcome after adjuvant therapy with anastrozole in breast cancer patients. We aimed to investigate predictive effect of BMI on clinical response to neoadjuvant therapy with exemestane in postmenopausal patients with primary breast cancer. Patients and methods: The study group consisted of 109 patients from the JFMC 34-0601 neoadjuvant endocrine therapy trial. Patients were categorized into three groups according to BMI: low (BMI<22kg/m2), intermediate (22≤BMI<25kg/m2) and high (BMI≥25kg/m2). Statistical analyses were performed to explore the predictive effect of BMI on clinical response. Results: Higher BMI correlated with positive progesterone receptor status (p<0.01) and low Ki-67 index (p=0.03). Objective response rates (ORR) were 21.7% in low BMI, 56.0% in intermediate BMI and 60.6% in high BMI, respectively (p=0.01). In a multivariate analysis, low BMI was an independent negative predictor of clinical response. Conclusion: Low BMI was associated with a decreased ORR to neoadjuvant endocrine therapy with exemestane. Our results may suggest that the predictive effect of BMI varies according to the type of aromatase inhibitor and objective outcome.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalBreast
Volume21
Issue number1
DOIs
Publication statusPublished - 2012 Feb

Keywords

  • Aromatase inhibitor
  • Body mass index
  • Breast cancer
  • Exemestane
  • Neoadjuvant hormonal therapy
  • Predictive factor

ASJC Scopus subject areas

  • Surgery

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