In order to assess the effect of vitamin D receptor(VDR) gene polymorphisms on vitamin D3 therapy for postmenopausal bone loss. 34 japanease postmenopausal women, administerd vitamin D3 (Alfarol 1.0 n g/day) and Ca (2.0g/day) for 18 months, were analyzed by RFLP method. Bone mineral density(BMD) at the lumber spine (L2-4) and Oscalcis were measured every 6 months by dual energy X-ray absorptiometry (DXA) and single energy X-ray absorptiometry (SXA). VDR-gene allelic polymorphisms were assessed by Bsm 1 endonuclease restriction after specific PCR amplification. Genotypic polymorphism was defined as BB, bb and Bb. The genotypes were BB in 1(3.1%), Bb in 13(40.6%), and bb in 18 (56.3%).The women with these two major VDR genotype groups (Bb and bb) were similar in their backgrounds (terms of age, menopausal age, body mass index, and BMD in premedication). However, VDR genotype was associated with the percent of change of BMD after treatment. In Group-Bb, the mean percent increase in L2-4 BMD were 3.2%, 4.9% and 4.1% at each 6,12 and 18 months. In contrast, in Group-bb were 0.8%, 1.8% and 1.2% at the same points.Analysis of VDR alleles may prove useful in selection of vitamin D therapy for osteopenia before treatment.
|Number of pages||1|
|Journal||Japanese Journal of Human Genetics|
|Publication status||Published - 1997|
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