TY - JOUR
T1 - Relation between nocturnal decline in blood pressure and mortality
T2 - The Ohasama study
AU - Ohkubo, Takayoshi
AU - Imai, Yutaka
AU - Tsuji, Ichiro
AU - Nagai, Kenichi
AU - Watanabe, Noriko
AU - Minami, Naoyoshi
AU - Kato, Junko
AU - Kikuchi, Noriko
AU - Nishiyama, Akimitsu
AU - Aihara, Akiko
AU - Sekino, Makoto
AU - Satoh, Hiroshi
AU - Hisamichi, Shigeru
N1 - Funding Information:
This work was supported by research grants from the Miyagi Prefectural Kidney Association, from the Takeda Medical Research Foundation, from the National Center for Cardiovascular Disease (No. 4C-3, 5C-2), from the Ministry of Health and Welfare (Evaluation of the Effect of Drug Treatment on Hypertension and Other Chronic Disease Conditions in the Elderly, Kosei-Kagaku Kenkyuhi 1996 and Rojin Hoken Jigyo Suishin Hojokin 1996), and from the Ministry of Education, Science and Culture (No. 07670420) of Japan.
PY - 1997/11
Y1 - 1997/11
N2 - To investigate the relation between nocturnal decline in blood pressure and mortality, we obtained ambulatory blood pressures in 1542 residents aged 40 years or over of a rural Japanese community. Subjects were followed-up for a mean of 5.1 years and were then subdivided into four groups according to the percent decline in nocturnal blood pressure: 1) extreme dippers: percent decline in nocturnal blood pressure ≤ 20% of the daytime blood pressure; 2) dippers: decline of ≤ 10% but < 20%; 3) nondippers: decline of ≤ 0% but < 10%; and 4)inverted dippers: no decline. The relationship between the decline in nocturnal blood pressure and mortality was examined by the Cox proportional hazards regression model adjusted for age, sex, smoking status, previous history of cardiovascular disease, and the use of antihypertensive medication. The mortality risk was highest in inverted dippers, followed by nondippers. There was no difference in mortality between extreme dippers and dippers. This relationship was observed for both treated and untreated subjects, was more pronounced for cardiovascular than for noncardiovascular mortality, and did not change after the data were adjusted for 24-h, daytime, and nighttime blood pressure levels.
AB - To investigate the relation between nocturnal decline in blood pressure and mortality, we obtained ambulatory blood pressures in 1542 residents aged 40 years or over of a rural Japanese community. Subjects were followed-up for a mean of 5.1 years and were then subdivided into four groups according to the percent decline in nocturnal blood pressure: 1) extreme dippers: percent decline in nocturnal blood pressure ≤ 20% of the daytime blood pressure; 2) dippers: decline of ≤ 10% but < 20%; 3) nondippers: decline of ≤ 0% but < 10%; and 4)inverted dippers: no decline. The relationship between the decline in nocturnal blood pressure and mortality was examined by the Cox proportional hazards regression model adjusted for age, sex, smoking status, previous history of cardiovascular disease, and the use of antihypertensive medication. The mortality risk was highest in inverted dippers, followed by nondippers. There was no difference in mortality between extreme dippers and dippers. This relationship was observed for both treated and untreated subjects, was more pronounced for cardiovascular than for noncardiovascular mortality, and did not change after the data were adjusted for 24-h, daytime, and nighttime blood pressure levels.
KW - Mortality
KW - Nocturnal decline in blood pressure
KW - Population-based subjects
KW - Prospective study
UR - http://www.scopus.com/inward/record.url?scp=0031280188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031280188&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(97)00274-4
DO - 10.1016/S0895-7061(97)00274-4
M3 - Article
C2 - 9397237
AN - SCOPUS:0031280188
VL - 10
SP - 1201
EP - 1207
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 11
ER -