Relation between blood flow and tissue blood oxygenation in human fingertip skin

Motohide Ikawa, Keishiro Karita

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Tissue blood flow (BF) is thought to be involved in the regulation of tissue blood oxygenation (StO2). The purpose of the present study was to show the relation between BF and StO2 by measuring them simultaneously under different conditions. Methods: Twenty-one healthy subjects (age 21-30years) participated in this study. We measured BF and StO2 in a small area of skin (fingertip, palm, forearm) simultaneously using a laser Doppler flowmeter and a tissue oxygenation monitor. Three measurements were made at rest while performing mental arithmetic and during constriction of the ipsilateral upper arm. Results: At rest, BF and StO2 were higher in the fingertip than in the palm or forearm (p<0.01). Performing mental arithmetic produced significant decreases in BF, oxygenated hemoglobin, and StO2 in the fingertip (p<0.05). Constriction of the ipsilateral upper arm produced significant decreases in BF and StO2 (p<0.05) and an increase in oxygenated hemoglobin (p<0.05). Both procedures produced significant increases in deoxygenated hemoglobin (p<0.05), which was in antiphase to the decrease in StO2. Conclusions: BF decrease produced a significantly decreased StO2 in fingertip skin. The results show that simultaneous measurement of BF and StO2 is beneficial for showing the close relation between them.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalMicrovascular Research
Volume101
DOIs
Publication statusPublished - 2015 Sep 1

Keywords

  • Blood flow
  • Human
  • Laser Doppler
  • Oxygenation
  • Skin

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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