Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha

Keisuke Tachibana, Naohiko Anzai, Chihiro Ueda, Tatsuya Katayama, Daisuke Yamasaki, Takayoshi Kirino, Rika Takahashi, Kenji Ishimoto, Hidenori Komori, Toshiya Tanaka, Takao Hamakubo, Yukihiko Ueda, Hiroyuki Arai, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARα and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARα regulates PDZK1 expression.

Original languageEnglish
Pages (from-to)3884-3888
Number of pages5
JournalFEBS Letters
Volume582
Issue number28
DOIs
Publication statusPublished - 2008 Nov 26

Keywords

  • PDZK1
  • PPARα
  • PPRE
  • Target gene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Tachibana, K., Anzai, N., Ueda, C., Katayama, T., Yamasaki, D., Kirino, T., Takahashi, R., Ishimoto, K., Komori, H., Tanaka, T., Hamakubo, T., Ueda, Y., Arai, H., Sakai, J., Kodama, T., & Doi, T. (2008). Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. FEBS Letters, 582(28), 3884-3888. https://doi.org/10.1016/j.febslet.2008.10.027