Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain

Kazuhiro Tsuruma, Tadashi Nakagawa, Hiromi Shirakura, Naoko Hayashi, Takashi Uehara, Yasuyuki Nomura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Caspases are the primary executioners of apoptosis. Although procaspases believe to exist as inactive forms in cells, the detailed regulatory system remains unclear. Here we show that glucocorticoid modulatory element-binding protein 1 (GMEB1) is capable of binding to the prodomain of caspase-2. We found that this molecule inhibits the autoproteolytic activation of procaspase-2 by oligomerization on a chemical compound-dependent system. These findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation.

Original languageEnglish
Pages (from-to)1246-1251
Number of pages6
JournalBiochemical and biophysical research communications
Volume325
Issue number4
DOIs
Publication statusPublished - 2004 Dec 24
Externally publishedYes

Keywords

  • Apoptosis
  • CARD domain
  • Caspase-2
  • Initiator caspase
  • Interacting protein
  • Regulation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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