[Regulation of osteoclast development by immunoglobulin-like receptors].

Masanori Inui, Toshiyuki Takai

Research output: Contribution to journalReview articlepeer-review


Immunoglobulin-like receptors (IgLR) , expressed in a wide range of cells in immune system, provide a positive and negative regulation of immune responses. Activation signals initiated by activating IgLR associating with ITAM-containing adapter proteins DAP12 and FcRγ are indispensable for the development of osteoclasts. On the other hand, ITIM signals induced by inhibitory IgLR regulate osteoclast development and activation. Thus, ITAM and ITIM play important roles in the maintenance of bone homeostasis.

Original languageEnglish
Pages (from-to)1651-1657
Number of pages7
JournalClinical calcium
Issue number11
Publication statusPublished - 2012 Nov

ASJC Scopus subject areas

  • Medicine(all)


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