Regulation of Necroptosis by Phospholipids and Sphingolipids

Xuewei Zhang; Masaya Matsuda; Nobuo Yaegashi; Takeshi Nabe; Kazuyuki Kitatani

doi:10.3390/cells9030627

Regulation of Necroptosis by Phospholipids and Sphingolipids

Xuewei Zhang, Masaya Matsuda, Nobuo Yaegashi, Takeshi Nabe, Kazuyuki Kitatani

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

Original language	English
Journal	Cells
Volume	9
Issue number	3
DOIs	https://doi.org/10.3390/cells9030627
Publication status	Published - 2020 Mar 5

Keywords

ceramide
fatty acids
lipids
mixed lineage kinase-domain like
necroptosis
phosphatidylinositols

ASJC Scopus subject areas

Medicine(all)

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title = "Regulation of Necroptosis by Phospholipids and Sphingolipids",

abstract = "Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.",

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author = "Xuewei Zhang and Masaya Matsuda and Nobuo Yaegashi and Takeshi Nabe and Kazuyuki Kitatani",

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month = mar,

day = "5",

doi = "10.3390/cells9030627",

language = "English",

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journal = "Cells",

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TY - JOUR

T1 - Regulation of Necroptosis by Phospholipids and Sphingolipids

AU - Zhang, Xuewei

AU - Matsuda, Masaya

AU - Yaegashi, Nobuo

AU - Nabe, Takeshi

AU - Kitatani, Kazuyuki

PY - 2020/3/5

Y1 - 2020/3/5

N2 - Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

AB - Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.

KW - ceramide

KW - fatty acids

KW - lipids

KW - mixed lineage kinase-domain like

KW - necroptosis

KW - phosphatidylinositols

UR - http://www.scopus.com/inward/record.url?scp=85096826505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85096826505&partnerID=8YFLogxK

U2 - 10.3390/cells9030627

DO - 10.3390/cells9030627

M3 - Review article

C2 - 32151027

AN - SCOPUS:85096826505

VL - 9

JO - Cells

JF - Cells

SN - 2073-4409

IS - 3

ER -

Regulation of Necroptosis by Phospholipids and Sphingolipids

Abstract

Keywords

ASJC Scopus subject areas

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