Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer

Jianwu Bai, Yoshihiko Uehara, Denise J. Montell

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Steroid hormones are key regulators of numerous physiological and developmental processes, including metastasis of breast and ovarian cancer. Here we report the identification of a Drosophila gene, named taiman, which encodes a steroid hormone receptor coactivator related to AIB1. Mutations in tai caused defects in the migration of specific follicle cells, the border cells, in the Drosophila ovary. Mutant cells exhibited abnormal accumulation of E-cadherin, β-catenin, and focal adhesion kinase. TAI protein colocalized with the ecdysone receptor in vivo and augmented transcriptional activation by the ecdysone receptor in cultured cells. The finding of this type of coactivator required for cell motility suggests a novel role for steroid hormones, in stimulating invasive cell behavior, independent of effects on proliferation.

Original languageEnglish
Pages (from-to)1047-1058
Number of pages12
JournalCell
Volume103
Issue number7
DOIs
Publication statusPublished - 2000 Dec 22

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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