Regulation of insulin gene transcription

Kinuko Ohneda, Hooi Ee, Michael German

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Recent studies of the insulin gene promoter and the transcription factors that regulate it have expanded our understanding of both how the production of insulin is restricted to the pancreatic β-cell, and how that production is regulated by physiologic signals such as glucose. A picture is emerging in which an elaborate set of transcription factors binds to specific sequences along the promoter and recruits additional transcriptional co-activators to build a functional transcriptional activation complex that is unique to β-cells. Surprisingly, however, genetic experiments in mice have demonstrated an unexpected degree of redundancy in the factors that control insulin gene expression, and have revealed the presence of a network of transcription factors that coordinate the expression of factors forming the insulin gene activation complex.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume11
Issue number4
DOIs
Publication statusPublished - 2000

Keywords

  • BETA2
  • Glucose
  • Insulin gene
  • NeuroD1
  • Transcription

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Regulation of insulin gene transcription'. Together they form a unique fingerprint.

  • Cite this