Regulation of dopaminergic neuronal activity by heart-type fatty acid binding protein in the brain

Yui Yamamoto, Norifumi Shioda, Yuji Owada, Kohji Fukunaga

Research output: Contribution to journalReview article

Abstract

Haloperidol as a potent dopamine D2 receptor (D2R) antagonist was a major tranquilizer to treat schizophrenia patients. However, the D2R blocking action in dorsal striatum is thought to cause extrapyramidal symptoms as adverse effects. However, the pathophysiological mechanism underlying extrapramidal symptoms induced by chronic treatment of haloperidol remains unclear. We recently found that lacking of heart-type fatty acid binding protein (H-FABP) in the brain aggravate catalepsy behavior induced by haloperidol. Here, we examined neuronal mechanism of augmentation of haloperidol-induced catalepsy in H-FABP null mice. Notably, catalepsy induced by haloperidol, a D2 antagonist, is augmented, whereas catalepsy induced by SCH23390, a D1 antagonist, was not affected in H-FABP null mice. Interestingly, haloperidol-induced acetylcholine (ACh) release in the dorsal striatum was markedly enhanced in H-FABP null mice compared to wild mice. We also defined the co-localization of D2R with H-FABP in the ACh interneurons in the striatum. Taken together, H-FABP regulates dopaminergic neuronal activity through interaction with D2R in rodent brain. The increased ACh release in the striatum accounts for haloperidol-induced cataleps.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalYakugaku Zasshi
Volume131
Issue number4
DOIs
Publication statusPublished - 2011 Apr 11

Keywords

  • Catalepsy
  • Dopamine D2 receptor
  • Extrapyramidal symptom
  • Haloperidol
  • Heart-type fatty acid binding protein

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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