Regulation of catalytic activity of peptide-heme conjugate by conformational change with trifluoroethanol

Seiji Sakamoto; Hidekazu Fukushima; Kazuaki Kudo

doi:10.1246/cl.2006.584

Regulation of catalytic activity of peptide-heme conjugate by conformational change with trifluoroethanol

Seiji Sakamoto, Hidekazu Fukushima, Kazuaki Kudo

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

Abstract

A peptide-heme conjugate in which two α-helix segments were covalently coupled at the heme propionates was designed, and the relationship between the structure and the peroxidase-like catalytic activity was examined. The activity and coordination state of heme were regulated by the conformational change of peptide induced upon the addition of trifluoroethanol.

Original language	English
Pages (from-to)	584-585
Number of pages	2
Journal	Chemistry Letters
Volume	35
Issue number	6
DOIs	https://doi.org/10.1246/cl.2006.584
Publication status	Published - 2006 Jun 5

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2006.584

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abstract = "A peptide-heme conjugate in which two α-helix segments were covalently coupled at the heme propionates was designed, and the relationship between the structure and the peroxidase-like catalytic activity was examined. The activity and coordination state of heme were regulated by the conformational change of peptide induced upon the addition of trifluoroethanol.",

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AB - A peptide-heme conjugate in which two α-helix segments were covalently coupled at the heme propionates was designed, and the relationship between the structure and the peroxidase-like catalytic activity was examined. The activity and coordination state of heme were regulated by the conformational change of peptide induced upon the addition of trifluoroethanol.

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Regulation of catalytic activity of peptide-heme conjugate by conformational change with trifluoroethanol

Abstract

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