Regulation of bone and cartilage development by network between BMP signalling and transcription factors

Riko Nishimura, Kenji Hata, Takuma Matsubara, Makoto Wakabayashi, Toshiyuki Yoneda

    Research output: Contribution to journalReview articlepeer-review

    112 Citations (Scopus)

    Abstract

    Bone morphogenetic protein(s) (BMP) are very powerful cytokines that induce bone and cartilage formation. BMP also stimulate osteoblast and chondrocyte differentiation. During bone and cartilage development, BMP regulates the expression and/or the function of several transcription factors through activation of Smad signalling. Genetic studies revealed that Runx2, Osterix and Sox9, all of which function downstream of BMP, play essential roles in bone and/or cartilage development. In addition, two other transcription factors, Msx2 and Dlx5, which interact with BMP signalling, are involved in bone and cartilage development. The importance of these transcription factors in bone and cartilage development has been supported by biochemical and cell biological studies. Interestingly, BMP is regulated by several negative feedback systems that appear necessary for fine-tuning of bone and cartilage development induced by BMP. Thus, BMP harmoniously regulates bone and cartilage development by forming network with several transcription factors.

    Original languageEnglish
    Pages (from-to)247-254
    Number of pages8
    JournalJournal of biochemistry
    Volume151
    Issue number3
    DOIs
    Publication statusPublished - 2012 Mar

    Keywords

    • BMP
    • bone
    • cartilage
    • transcription factors

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology

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