TY - JOUR
T1 - Regulation of bone and cartilage development by network between BMP signalling and transcription factors
AU - Nishimura, Riko
AU - Hata, Kenji
AU - Matsubara, Takuma
AU - Wakabayashi, Makoto
AU - Yoneda, Toshiyuki
N1 - Funding Information:
Ministry of Education, Science, Sports and Culture Grants-in-Aid for Scientific Research (partial); The Uehara Memorial Foundation (partial); The Astellas Foundation for Research on Metabolic Disorders (partial).
PY - 2012/3
Y1 - 2012/3
N2 - Bone morphogenetic protein(s) (BMP) are very powerful cytokines that induce bone and cartilage formation. BMP also stimulate osteoblast and chondrocyte differentiation. During bone and cartilage development, BMP regulates the expression and/or the function of several transcription factors through activation of Smad signalling. Genetic studies revealed that Runx2, Osterix and Sox9, all of which function downstream of BMP, play essential roles in bone and/or cartilage development. In addition, two other transcription factors, Msx2 and Dlx5, which interact with BMP signalling, are involved in bone and cartilage development. The importance of these transcription factors in bone and cartilage development has been supported by biochemical and cell biological studies. Interestingly, BMP is regulated by several negative feedback systems that appear necessary for fine-tuning of bone and cartilage development induced by BMP. Thus, BMP harmoniously regulates bone and cartilage development by forming network with several transcription factors.
AB - Bone morphogenetic protein(s) (BMP) are very powerful cytokines that induce bone and cartilage formation. BMP also stimulate osteoblast and chondrocyte differentiation. During bone and cartilage development, BMP regulates the expression and/or the function of several transcription factors through activation of Smad signalling. Genetic studies revealed that Runx2, Osterix and Sox9, all of which function downstream of BMP, play essential roles in bone and/or cartilage development. In addition, two other transcription factors, Msx2 and Dlx5, which interact with BMP signalling, are involved in bone and cartilage development. The importance of these transcription factors in bone and cartilage development has been supported by biochemical and cell biological studies. Interestingly, BMP is regulated by several negative feedback systems that appear necessary for fine-tuning of bone and cartilage development induced by BMP. Thus, BMP harmoniously regulates bone and cartilage development by forming network with several transcription factors.
KW - BMP
KW - bone
KW - cartilage
KW - transcription factors
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U2 - 10.1093/jb/mvs004
DO - 10.1093/jb/mvs004
M3 - Review article
C2 - 22253449
AN - SCOPUS:84858200481
VL - 151
SP - 247
EP - 254
JO - Journal of Biochemistry
JF - Journal of Biochemistry
SN - 0021-924X
IS - 3
ER -