Regulation of airway responsiveness by dopamine receptor signaling pathways

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, we have demonstrated that dopamine receptor subtypes are expressed on airway smooth muscle (ASM) and modulates ASM function. We detected the expression of dopamine D1 and D2 receptors in ASM. Dopamine D1 receptor agonist stimulated cAMP production in human ASM cells and dose- dependently relaxed guinea pig ASM. Acute activation of the dopamine D2 receptor in human ASM cells inhibited forskolin-stimulated adenylyl cyclase activity. On the other hand, chronic activation of the dopamine D2 receptor stimulated it, and potentiated forskolin-induced guinea pig ASM relaxation. These findings suggest that functional dopamine D1 and D2 receptors are expressed in ASM, and modulate ASM tone through adenylyl cyclase/cAMP signaling.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Pages359-361
Number of pages3
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
DOIs
Publication statusPublished - 2012 Jan 1

Keywords

  • Adenylyl cyclase
  • Airway smooth muscle
  • Asthma
  • Dopamine

ASJC Scopus subject areas

  • Dentistry(all)

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